The technology used to develop organoids stored in the Hubrecht Organoid Biobank is based on the discovery of Lgr5+ stem cells in the adult intestine by the Hans Clever’s lab, which subsequently led to the development of the fist “mini-gut in a dish”. This technology allows the development of organoids directly from patient biopsies and resections without requiring reprogramming or transformation of stem cells, therefore enabling to preserve the original tissue genetic and epigenetic make up, including clinically-relevant mutations.
HUB Organoids holds global IP rights for this technology. For more information on how to license HUB Organoid Technology for in-house applications please visit https://www.huborganoids.nl/licenses/
